LifeLine™ Software Suite - Library of Associated Documentation

Below is a collection of software documentation, presentations, and other literature related to The LifeLine Group,  LifeLine™ Software Suite, and topics relevant to aggregate and cumulative risk assessment software.

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LifeLine™ Software Suite - Version 5 Documentation

LifeLine™ Software Suite - Version 4.3 Documentation

Presentations at the Society for Risk Analysis 2003 Annual Meeting in Baltimore, Maryland

Presentations at the International Society for Exposure Assessment 2003 Annual Meeting in Stresa, Italy

Construction of a Comprehensive Chemical Exposure Framework Using Person Oriented Modeling, June 20, 2003
This report present a systematic discussion of the key issues for the design of software to assess cumulative and aggregate exposures to chemicals. The report presents a review of existing models, a framework for probabilistic models, and an application of the model framework to four case scenarios. The report was funded by the Exposure Technical Implementation Panel of the American Chemistry Council Contact # 1388.
PDF format, total size 571 KB

Cumulative Risk Assessment for Organophosphorus Pesticides Using LifeLine™, Performed for the U.S. EPA Office of Pesticide Programs by The LifeLine Group, Inc. Paul S. Price, Christine F. Chaisson, Eric Mathis, and Douglas Tedder, September 20, 2002
This report presents an assessment of the cumulative risks posed by Organophosphorus Pesticides using the assumptions established in the Agency's assessment June 11, 2002 assessment. The report is presented in the following files.

  • Title Page - PDF, 80 KB
  • Chapter 1: Introduction - PDF, 78 KB
  • Chapter 2: Dose Response Assessment - PDF, 48.5 KB
  • Chapter 3: Dietary Exposure - PDF, 188 KB
  • Chapter 4: Tap Water Exposure Assessment - PDF, 188 KB
  • Chapter 5: Residential Exposure Assessment - PDF, 239 KB
  • Chapter 6: Risk Characterization - PDF, 163 KB
  • Chapter 7: Risk Assessment for OP Pesticides and Results - PDF, 222 KB
  • Appendix A: Registration for LifeLine Software - PDF, 60 KB
  • Appendix B: Using the Food Residue Translator to Import OPCRA Data Files - PDF, 97 KB
  • Appendix C: Development of Empirical Input Distributions Required for the Residential Exposure Assessment - PDF, 107 KB
  • Appendix D: Derivation of Daily Percent Decline in Turf Transferable Residues and Dislodgeable Foliar Residues for Organophosphate Pesticides - PDF, 176 KB
  • Appendix E: Exposure Related Assumptions Associated with Specific NHAPS Activities and Ages - PDF, 68 KB
  • Appendix F: Toxicity and Residential Use Information in Input File, Opcumulative.rkg - PDF, 104 KB
  • Appendix G: Documentation of Tapwater Distributions in Tapwater Input File Opwater.twc - PDF, 62 KB

Input files used in the September 20, 2002 assessment of organophosphorous pesticides prepared by the LifeLine Group Inc. for USEPA.
This folder contains four files that describe the inputs for the cumulative assessment of organophosphorous pesticides. These files and LifeLine™ will allow any interested individual to independently verify the findings presented in the September 20, 2002 report Cumulative Risk Assessment for Organophosphorus Pesticides Using LifeLine™.
ZIP format, total size 691 KB (compressed)

SAP Report on LifeLine March 2001
EPA's Science Advisory Report on LifeLine™ Version 1.0
PDF format, total size 89.2 Kb

Assessing Aggregate and Cumulative Pesticide Risks Using LifeLine™ Version 1.0
A report submitted to the EPA Science Advisory Panel, August 2000. This report provides the basis for the September 2000 presentation and the publication:

P. S. Price, J. S. Young, C. F. Chaisson. 2001. Assessing Aggregate and Cumulative Pesticide Risks Using A Probabilistic Model, Annals of Occupational Hygiene, Vol 45 No. 1001, S131-S142
PDF format, total size 512 KB

LifeLine Group Presentation to the US EPA/FIFRA Scientific Advisory Panel (SAP)
Presentation of the first cumulative risk assessment to the SAP, September 1999.
PDF format, total size 83.9 KB

LifeLine Group Related Publications

Franklin, C.A. and J.P.Worgan, Eds. Occupational and Residential Exposure Assessment for Pesticides, ISBN 0-471-48989-1, John Wiley & Sons Ltd. 2005.

Jayjock, M.A. How much is enough to accept hormesis as the default? Or ‘At what point, if ever, could/should hormesis be employed as the principal dose-response default assumption in risk assessment?’ Human & Experimental Toxicology, 24, 245-247. (2005).

Jayjock, M.A. Modeling Inhalation Exposure, Chapter 8 in The Occupational Environment – Its Evaluation and Control, American Industrial Hygiene Association, Fairfax, VA (2003).

Jayjock, M.A. Chapters 1 and 6 in Mathematical Models for Estimating Occupational Exposure to Chemicals, edited by C.B. Keil, American Industrial Hygiene Association, Fairfax, VA (2000).

Jayjock, M.A. Uncertainty Analysis in the Evaluation of Exposure, Am. Ind. Hyg. Assoc. J. 58 (5): 380-382 (1997).

Jayjock, M.A. Modeling Inhalation Exposure, chapter 16 in The Occupational Environment – Its Evaluation and Control, edited by S.R. DiNardi, American Industrial Hygiene Association, Fairfax, VA (1997).

Jayjock, M.A., P.S. Price, C.F. Chaisson.. Monte Carlo Analysis, Chapter in Encyclopedia of Toxicology, Philip Wexler (Ed),ISBN 0-12-745354-7, Elsevier, 2005.  

Jayjock, M.A. and P.G. Lewis. Implications of Hormesis for Industrial Hygiene, Human & Experimental Toxicology 21: 385-389 (2002).

Jayjock, M.A., J.R. Lynch and D.I. Nelson. Risk Assessment Principles for the Industrial Hygienist, American Industrial Hygiene Press, 2700 Prosperity Avenue, Fairfax, VA, May, 2000.

Jayjock, M.A. and J.E. Franke. A Strategy for Occupational Exposure Assessment, Appendix I, Estimating inhalation exposure with physical-chemical models, American Industrial Hygiene Association, Fairfax, VA (1998).

Jayjock, M.A., K.H. Reinert, H.E. Scribner, et al. Total Quality Management of the Risk Assessment Process, Am. Ind. Hyg. Assoc. J. 58 (11): 814-819 (1997).

M. Nicas and M.A. Jayjock. Uncertainty in Exposure Estimates Made by Modeling versus Monitoring, Am. Ind.Hyg. Assoc. J. 63: 275-283 (2002).

Weiler,E.D., O’Hara G.P., Shade, W.D., and Jayjock, M.A. Setting Workplace Exposure Limits: An Important Stewardship Function. Environmental Quality Management, Vol.14 No.2: 49-57 (2004).

Weiler, E.D., M.A. Jayjock, and H.C. Levy. Product Safety, Risk Assessment, and Responsible Care in the Biocide Chemical Industry, Reg Tox. Pharm. 24, 1-5 (1996).